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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-5-15
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pubmed:abstractText |
In human blood platelets verapamil and D600 (2-methoxyverapamil) in therapeutic concentrations inhibited the shape change reaction induced by 5-hydroxytryptamine (5HT) but not that induced by ADP. The N-methylated derivatives (D575 and D890) had much less effect. The inhibitory action of verapamil was independent of external Ca2+. Nitrendipine and diltiazem (20 microM) had no effect on the 5HT- and the ADP-induced shape change reactions. Since both these shape change reactions are mediated by a rise in cytoplasmic free Ca2+, it is concluded that the inhibition of the 5HT effect by verapamil and D600 was not due to their interference with calcium channels but rather to an antagonistic action on 5HT2-receptors. This view is supported by the finding that verapamil but not D575 competed with [3H]ketanserin and [3H]spiroperidol for their specific binding sites on membranes of rat cerebral cortex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3156755-Adenosine Diphosphate,
pubmed-meshheading:3156755-Binding, Competitive,
pubmed-meshheading:3156755-Blood Platelets,
pubmed-meshheading:3156755-Cerebral Cortex,
pubmed-meshheading:3156755-Gallopamil,
pubmed-meshheading:3156755-Humans,
pubmed-meshheading:3156755-Ketanserin,
pubmed-meshheading:3156755-Membranes,
pubmed-meshheading:3156755-Piperidines,
pubmed-meshheading:3156755-Receptors, Serotonin,
pubmed-meshheading:3156755-Spiperone,
pubmed-meshheading:3156755-Verapamil
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pubmed:year |
1985
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pubmed:articleTitle |
Verapamil, an antagonist at 5-hydroxytryptamine receptors of human blood platelets.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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