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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-4-16
|
| pubmed:abstractText |
We investigated the expression of Ia antigens on T-cells from lung and blood, as a sign of T-cell activation, in 17 patients with active pulmonary sarcoidosis, 12 patients with inactive sarcoidosis, 9 patients with hypersensitivity pneumonitis, and 10 normal control subjects. Lymphocyte subsets were identified by mouse monoclonal antibodies using a peroxidase-antiperoxidase method. Patients with active sarcoidosis and patients with hypersensitivity pneumonitis had a significant increase in Ia+ T-cells in bronchoalveolar lavage fluid compared with that in patients with inactive sarcoidosis and that in control subjects (p less than 0.01). Blood T-cells from the same patients did not show this sign of activation. The highest numbers of Ia+ T-cells were recovered from the lungs of patients with hypersensitivity pneumonitis, indicating the high state of activation of immunoregulatory T-cells in this disease. Additional analysis revealed that in sarcoidosis, Ia+ lung T-cells were exclusively of the OKT4+ helper phenotype, whereas in hypersensitivity pneumonitis, OKT4+ helper as well as OKT8+ suppressor lung cells expressed in part Ia antigens. These observations suggest that different T-cell subpopulations are activated in sarcoidosis and in hypersensitivity pneumonitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0003-0805
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
337-42
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3156547-Adolescent,
pubmed-meshheading:3156547-Adult,
pubmed-meshheading:3156547-Aged,
pubmed-meshheading:3156547-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:3156547-Bronchi,
pubmed-meshheading:3156547-Bronchoscopy,
pubmed-meshheading:3156547-Female,
pubmed-meshheading:3156547-Histocompatibility Antigens Class II,
pubmed-meshheading:3156547-Humans,
pubmed-meshheading:3156547-Lung Diseases,
pubmed-meshheading:3156547-Male,
pubmed-meshheading:3156547-Middle Aged,
pubmed-meshheading:3156547-Pneumonia,
pubmed-meshheading:3156547-Pulmonary Alveoli,
pubmed-meshheading:3156547-Sarcoidosis,
pubmed-meshheading:3156547-T-Lymphocytes,
pubmed-meshheading:3156547-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:3156547-T-Lymphocytes, Regulatory,
pubmed-meshheading:3156547-Therapeutic Irrigation
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Ia-like antigens on T-cells and their subpopulations in pulmonary sarcoidosis and in hypersensitivity pneumonitis. Analysis of bronchoalveolar and blood lymphocytes.
|
| pubmed:publicationType |
Journal Article
|