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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-4-15
|
| pubmed:abstractText |
A panel of 55 alloreactive murine T-lymphocyte clones was screened for the production of granulocyte-macrophage colony stimulating factor (GM-CSF), multilineage CSF (multi-CSF), human-active eosinophil CSF (human-active EO-CSF), and interleukin 2 (IL-2) in response to stimulation with the lectin concanavalin A. Many clones were also characterized for cytolytic specificity and expression of the T-cell antigen receptor-associated surface markers Lyt-2 and L3T4, which reflect their specificity for Class I (H-2K, H-2D) or Class II (H-2l, Mls) histocompatibility antigens, respectively. Eighty percent of the clones secreted detectable quantities of at least one of the four factors measured. Of the factor-producing clones, all appeared to secrete GM-CSF and half also secreted multi-CSF. A subpopulation of multi-CSF producers also released human-active EO-CSF. More than half of the factor-producing clones secreted detectable IL-2; whereas the IL-2-producing clones included some that did not secrete multi-CSF, IL-2 production was always associated with concomitant synthesis of GM-CSF. Comparison of the range and quantities of factors secreted by Lyt-2+ and L3T4+ clones indicated that more L3T4+ clones produced measurable titers of the four factors; on average, this group also secreted 10- to 100-fold higher titers of both the hemopoietic regulators and IL-2 than Lyt-2+ clones. Cells of the L3T4+ phenotype would therefore be expected to account for the majority of CSF and IL-2 secretion by polyclonal populations of activated T lymphocytes.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-9541
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
123
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
101-10
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3156138-Animals,
pubmed-meshheading:3156138-Antigens, Ly,
pubmed-meshheading:3156138-Clone Cells,
pubmed-meshheading:3156138-Colony-Stimulating Factors,
pubmed-meshheading:3156138-Concanavalin A,
pubmed-meshheading:3156138-Cytotoxicity, Immunologic,
pubmed-meshheading:3156138-Eosinophils,
pubmed-meshheading:3156138-Female,
pubmed-meshheading:3156138-Granulocytes,
pubmed-meshheading:3156138-Histocompatibility Antigens,
pubmed-meshheading:3156138-Interleukin-2,
pubmed-meshheading:3156138-Lymphocyte Activation,
pubmed-meshheading:3156138-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:3156138-Macrophages,
pubmed-meshheading:3156138-Mice,
pubmed-meshheading:3156138-Mice, Inbred C57BL,
pubmed-meshheading:3156138-Mice, Inbred CBA,
pubmed-meshheading:3156138-Mice, Inbred DBA,
pubmed-meshheading:3156138-Phenotype,
pubmed-meshheading:3156138-T-Lymphocytes
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Clonal heterogeneity in colony stimulating factor production by murine T lymphocytes.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|