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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-4-15
|
| pubmed:abstractText |
A patient with Sézary's syndrome is described. Surface marker analysis of her peripheral blood lymphocytes exhibit a phenotype characteristic of mature helper T cells (OKT3+, OKT4+, OKT8-, OKT6-). Serological studies revealed a polyclonal hyperimmunoglobulinemia with large amounts of IgE and IgA and circulating immune complexes that activate the complementary system via alternative pathway. The patient's cells showed a helper activity on normal B cell differentiation after a 7-day co-culture with pokeweed mitogen. The relevance of this helper phenotype and the function on in vivo polyclonal B cell activation is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0020-5915
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
282-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3156095-Aged,
pubmed-meshheading:3156095-Antigen-Antibody Complex,
pubmed-meshheading:3156095-B-Lymphocytes,
pubmed-meshheading:3156095-Cell Differentiation,
pubmed-meshheading:3156095-Female,
pubmed-meshheading:3156095-Humans,
pubmed-meshheading:3156095-Immunoglobulin E,
pubmed-meshheading:3156095-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:3156095-Sezary Syndrome,
pubmed-meshheading:3156095-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Sézary's syndrome: a case with blood T-lymphocytes of helper phenotype, elevated IgE levels and circulating immune complexes.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|