| pubmed-article:3156014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0025011 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:3156014 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:3156014 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3156014 | pubmed:dateCreated | 1985-4-5 | lld:pubmed |
| pubmed-article:3156014 | pubmed:abstractText | Measles virus (MV) is known to depress T cell function. In order to determine whether this results from alteration in the production of, or response to, interleukin-2 (IL-2) we studied the effect of in vitro infection with MV on human IL-2 dependent T cell lines. MV produced a cytopathic productive infection in these cells. Class I allospecific cytotoxic T cells retained their cytotoxic activity 48 h after infection. Both cytotoxic and Leu 3a/4a positive T cell lines continued to respond to IL-2 by proliferation up to 26 h after infection. The ability of human tonsillar lymphocytes to generate IL-2 in response to phytohaemagglutinin following MV infection was then studied. In early measles infection (up to 48 h) there was no suppression of IL-2 production: in fact measles infected cells spontaneously released low levels of IL-2 in the absence of lectin. Similarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2. These observations suggest that MV-induced immunosuppression is not a result of inhibition of differentiated T cell function, IL-2 generation or responsiveness, but may be more directly related to virus-induced cytopathic effects in activated T cells. | lld:pubmed |
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| pubmed-article:3156014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3156014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3156014 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3156014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3156014 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3156014 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:3156014 | pubmed:author | pubmed-author:CasalsJJ | lld:pubmed |
| pubmed-article:3156014 | pubmed:author | pubmed-author:SissonsJ GJG | lld:pubmed |
| pubmed-article:3156014 | pubmed:author | pubmed-author:RogersBB | lld:pubmed |
| pubmed-article:3156014 | pubmed:author | pubmed-author:MorrisSS | lld:pubmed |
| pubmed-article:3156014 | pubmed:author | pubmed-author:BorysiewiczL... | lld:pubmed |
| pubmed-article:3156014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3156014 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:3156014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3156014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3156014 | pubmed:pagination | 29-36 | lld:pubmed |
| pubmed-article:3156014 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3156014 | pubmed:meshHeading | pubmed-meshheading:3156014-... | lld:pubmed |
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| pubmed-article:3156014 | pubmed:meshHeading | pubmed-meshheading:3156014-... | lld:pubmed |
| pubmed-article:3156014 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3156014 | pubmed:articleTitle | The immunosuppressive effects of measles virus on T cell function--failure to affect IL-2 release or cytotoxic T cell activity in vitro. | lld:pubmed |
| pubmed-article:3156014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3156014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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