Linked Life Data

3156014

Source:http://linkedlifedata.com/resource/pubmed/id/3156014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-4-5
pubmed:abstractText
Measles virus (MV) is known to depress T cell function. In order to determine whether this results from alteration in the production of, or response to, interleukin-2 (IL-2) we studied the effect of in vitro infection with MV on human IL-2 dependent T cell lines. MV produced a cytopathic productive infection in these cells. Class I allospecific cytotoxic T cells retained their cytotoxic activity 48 h after infection. Both cytotoxic and Leu 3a/4a positive T cell lines continued to respond to IL-2 by proliferation up to 26 h after infection. The ability of human tonsillar lymphocytes to generate IL-2 in response to phytohaemagglutinin following MV infection was then studied. In early measles infection (up to 48 h) there was no suppression of IL-2 production: in fact measles infected cells spontaneously released low levels of IL-2 in the absence of lectin. Similarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2. These observations suggest that MV-induced immunosuppression is not a result of inhibition of differentiated T cell function, IL-2 generation or responsiveness, but may be more directly related to virus-induced cytopathic effects in activated T cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-126271, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-203630, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-308511, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-334153, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-4201441, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-4356690, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-5324645, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-5762650, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6172026, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6175576, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6196203, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6300245, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6444548, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6808028, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6966202, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-6966650, http://linkedlifedata.com/resource/pubmed/commentcorrection/3156014-804515
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-36
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The immunosuppressive effects of measles virus on T cell function--failure to affect IL-2 release or cytotoxic T cell activity in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't