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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-4-1
|
| pubmed:abstractText |
The cellular requirements for stimulating primed alloreactive T cells have been investigated. In vitro-primed secondary alloreactive cells, long-term lines, and Ly 1+2- noncytolytic clones which reacted with allo-H-2K, D, or Mls (M locus) antigens were tested. The data indicated that a specialized antigen-presenting cell such as a macrophage or a dendritic cell was required for stimulating primed alloreactive cells across all the genetic disparities tested. B and T lymphocytes were ineffective stimulators. The stimulator requirement for secondary and Ly 1+2- clone responses was heterogeneous, since both macrophages and dendritic cells were effective stimulators. Thus, the allostimulator requirement for inducing proliferation and mediator secretion by the primed T-cell populations closely paralleled the requirement for stimulating unprimed populations. The only exception found was the peritoneal washout population, which did not stimulate a primary response but did stimulate secondary responses. The failure of peritoneal macrophages to stimulate a primary response was shown to be due to an inhibitory pathway which did not occur when the responding population was alloantigen primed.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b)
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0008-8749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
60-74
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3156000-Animals,
pubmed-meshheading:3156000-Antibodies, Monoclonal,
pubmed-meshheading:3156000-Antigen-Presenting Cells,
pubmed-meshheading:3156000-Binding, Competitive,
pubmed-meshheading:3156000-Cell Adhesion,
pubmed-meshheading:3156000-Clone Cells,
pubmed-meshheading:3156000-H-2 Antigens,
pubmed-meshheading:3156000-Haploidy,
pubmed-meshheading:3156000-Histocompatibility Antigens Class II,
pubmed-meshheading:3156000-Lymphocyte Activation,
pubmed-meshheading:3156000-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:3156000-Macrophages,
pubmed-meshheading:3156000-Mice,
pubmed-meshheading:3156000-Mice, Inbred C57BL,
pubmed-meshheading:3156000-Mice, Inbred DBA,
pubmed-meshheading:3156000-Peritoneal Cavity,
pubmed-meshheading:3156000-Receptors, Antigen, B-Cell,
pubmed-meshheading:3156000-Spleen,
pubmed-meshheading:3156000-T-Lymphocytes
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Stimulator requirements for primed alloreactive T cells: macrophages and dendritic cells activate T cells across all genetic disparities.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|