Linked Life Data

3155680

Source:http://linkedlifedata.com/resource/pubmed/id/3155680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-2-26
pubmed:abstractText
The present study employed the dehydroepiandrosterone (DHA) loading test to determine if the placenta in baboons remains functional following fetectomy. A bolus iv injection of 100 mg DHA was given to 4 baboons prior to and at various intervals following fetectomy at midgestation. Blood samples were withdrawn over a 4-h period following DHA and assayed for estradiol (E2). Placentas were maintained in situ following removal of the fetus. Serum E2 reached peak concentrations 30-60 min after injection of DHA prior to and after fetectomy. Although initial serum E2 concentrations were very low after fetectomy, the mean +/- SE net increase (delta) in peak serum E2 concentrations following the DHA bolus were similar before (3.92 +/- 0.71 ng/ml) and after (3.72 +/- 0.64 ng/ml) fetectomy. Based on the capacity for aromatization, therefore, the placenta remains equally competent and functional in baboons despite chronic absence of the fetus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
843-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The placenta remains functional following fetectomy in baboons.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.