Linked Life Data

3155424

Source:http://linkedlifedata.com/resource/pubmed/id/3155424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-3-3
pubmed:abstractText
Effects of antiprogesterone RU38486 were studied in rats. The synthetic compound effectively (100%) inhibited implantation when administered on day 2 as well as on day 4 postconception (2.5mg/kg, in glycerol). This treatment, however, did not alter circulating estradiol and progesterone levels. Fertilized ovum yielded on day 4 from the uterine cavity showed normal morphology including adequate progress in cell division. A light microscopic study of the endometrium showed decreased cytoplasmic vacuole formation but estrogenic effects were apparently preserved. These data suggest that administration of RU38486 immediately after conception could successfully prevent implantation without altering early luteotropic functions in rats. Also the high dose of the compound was found to have no significant toxic effects on fertilized ovum, indicating that the anticonceptional action of RU38486 mainly functions at the uterine endometrial level.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1709-14
pubmed:dateRevised
2011-7-29
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Effects of RU38486, an antiprogesterone agent, on endometrium, fertilized ovum and serum sex steroid levels in rats].
pubmed:affiliation
Department of Obstetrics and Gynecology, Nihon University, School of Medicine, Tokyo.
pubmed:publicationType
Journal Article, English Abstract