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rdf:type |
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lifeskim:mentions |
umls-concept:C0001492,
umls-concept:C0018321,
umls-concept:C0021469,
umls-concept:C0036140,
umls-concept:C0037473,
umls-concept:C0037494,
umls-concept:C0220905,
umls-concept:C0449432,
umls-concept:C0542341,
umls-concept:C1179435,
umls-concept:C1280500,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1709059,
umls-concept:C1882726
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pubmed:issue |
2-3
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pubmed:dateCreated |
1989-5-30
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pubmed:abstractText |
We have examined the effects of sodium (Na+) salts on rat liver adenylate cyclase. Increasing concentrations of Na+ salts produced biphasic stimulation and inhibition of adenylate cyclase and potentiated enzyme activation by GTP and its hydrolysis resistant analog 5'-guanylyl imidodiphosphate. Salt effects were temperature dependent, of rapid onset, and specific for the Na+ cation though also partly dependent on the accompanying anion. Sodium salt stimulation of adenylate cyclase and enhancement of GTP activation were attenuated by agents (pertussis toxin and N-ethylmaleimide) which inactivate the inhibitory guanine nucleotide-binding regulatory component (Gi) of adenylate cyclase. Cholera toxin, which activates the stimulatory guanine nucleotide-binding regulatory component (Gs) of adenylate cyclase and thereby increases enzyme activity, augmented the inhibitory phase of Na+ salt action. These results suggest that the stimulatory and inhibitory effects of Na+ salts may be due, respectively, to inhibition of Gi and Gs modulation of adenylate cyclase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Azides,
http://linkedlifedata.com/resource/pubmed/chemical/Cations, Monovalent,
http://linkedlifedata.com/resource/pubmed/chemical/Cholera Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylmaleimide,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Manganese,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Azide,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella
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pubmed:status |
MEDLINE
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pubmed:issn |
0895-7479
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-21
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3149674-Adenylate Cyclase,
pubmed-meshheading:3149674-Adenylate Cyclase Toxin,
pubmed-meshheading:3149674-Animals,
pubmed-meshheading:3149674-Azides,
pubmed-meshheading:3149674-Cations, Monovalent,
pubmed-meshheading:3149674-Cholera Toxin,
pubmed-meshheading:3149674-Dose-Response Relationship, Drug,
pubmed-meshheading:3149674-Ethylmaleimide,
pubmed-meshheading:3149674-GTP-Binding Proteins,
pubmed-meshheading:3149674-Liver,
pubmed-meshheading:3149674-Male,
pubmed-meshheading:3149674-Manganese,
pubmed-meshheading:3149674-Pertussis Toxin,
pubmed-meshheading:3149674-Rats,
pubmed-meshheading:3149674-Rats, Inbred Strains,
pubmed-meshheading:3149674-Sodium Azide,
pubmed-meshheading:3149674-Sodium Chloride,
pubmed-meshheading:3149674-Time Factors,
pubmed-meshheading:3149674-Virulence Factors, Bordetella
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pubmed:year |
1988
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pubmed:articleTitle |
Stimulatory and inhibitory effects of sodium salts on adenylate cyclase of rat liver. Implications for salt modulation of guanine nucleotide-binding regulatory component function.
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pubmed:affiliation |
Department of Medicine, University of Texas Health Science Center, San Antonio 78284.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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