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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
83
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pubmed:dateCreated |
1989-4-26
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pubmed:abstractText |
The effect of granulocyte/macrophage colony stimulating factor (GM-CSF) on macrophage activation by interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS) was studied in a murine model system. When peritoneal macrophages were pretreated with GM-CSF for 24 hrs, a strong reduction of IFN-gamma-induced tumor cytotoxicity and LPS-triggered tumor necrosis factor-alpha (TNF-alpha) release was found. In contrast, GM-CSF treatment of macrophages for only 4 to 8 hrs enhanced TNF-alpha production. These data suggest that GM-CSF may affect macrophage activation in a biphasic manner in that a time period of enhanced responsiveness to IFN-gamma is followed by a longlasting period of refractoriness.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0301-0457
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3149190-Animals,
pubmed-meshheading:3149190-Cell Line,
pubmed-meshheading:3149190-Cells, Cultured,
pubmed-meshheading:3149190-Colony-Stimulating Factors,
pubmed-meshheading:3149190-Cytotoxicity, Immunologic,
pubmed-meshheading:3149190-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:3149190-Growth Substances,
pubmed-meshheading:3149190-Interferon-gamma,
pubmed-meshheading:3149190-Lipopolysaccharides,
pubmed-meshheading:3149190-Macrophages,
pubmed-meshheading:3149190-Mice,
pubmed-meshheading:3149190-Mice, Inbred DBA,
pubmed-meshheading:3149190-Recombinant Proteins,
pubmed-meshheading:3149190-Tumor Necrosis Factor-alpha
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pubmed:year |
1988
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pubmed:articleTitle |
Reduction of macrophage-mediated tumor cytotoxicity by pretreatment with GM-CSF.
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pubmed:affiliation |
Institute of Immunology, University of Marburg, W.-Germany.
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pubmed:publicationType |
Journal Article
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