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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1979-12-20
|
| pubmed:abstractText |
In order to clarify whether the dorsal raphe (d-R) and medial raphe nuclei (m-R) of the midbrain play a different role in EEG activity, the effects of either electrical stimulation or lesion of each raphe nucleus were examined in rats. After m-R stimulation, EEG activity changed to a marked drowsy pattern. D-R stimulation, however, failed to produce such effects. M-R lesion elicited a significant arousal in EEG. The change in hippocampal EEG was the most characteristic, i.e., synchronized waves with an extreme increase in voltage. D-R lesion did not produce such a change. The hippocampal EEG arousal was easily abolished by L-5-hydroxytryptophan without any change in the cortical EEG or behavior. These results suggest that the m-R plays a more important role than the d-R in regulating the hippocampal EEG activity, especially in inhibiting the appearance of high voltage synchronized waves in the hippocampus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0361-9230
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
491-5
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:314836-5-Hydroxytryptophan,
pubmed-meshheading:314836-Amygdala,
pubmed-meshheading:314836-Animals,
pubmed-meshheading:314836-Arousal,
pubmed-meshheading:314836-Behavior, Animal,
pubmed-meshheading:314836-Brain Stem,
pubmed-meshheading:314836-Electric Stimulation,
pubmed-meshheading:314836-Electroencephalography,
pubmed-meshheading:314836-Evoked Potentials,
pubmed-meshheading:314836-Frontal Lobe,
pubmed-meshheading:314836-Hippocampus,
pubmed-meshheading:314836-Male,
pubmed-meshheading:314836-Mesencephalon,
pubmed-meshheading:314836-Neural Pathways,
pubmed-meshheading:314836-Raphe Nuclei,
pubmed-meshheading:314836-Rats,
pubmed-meshheading:314836-Septal Nuclei,
pubmed-meshheading:314836-Serotonin
|
| pubmed:articleTitle |
Effects of midbrain raphe stimulation and lesion on EEG activity in rats.
|
| pubmed:publicationType |
Journal Article
|