| pubmed-article:3147113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0001734 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C1512412 | lld:lifeskim |
| pubmed-article:3147113 | lifeskim:mentions | umls-concept:C0917995 | lld:lifeskim |
| pubmed-article:3147113 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3147113 | pubmed:dateCreated | 1989-3-27 | lld:pubmed |
| pubmed-article:3147113 | pubmed:abstractText | The acute hepatotoxicity induced by aflatoxin B1 (AFB1) and the potential protective effect of (+)-cyanidanol-3 (Catergen) were evaluated in both human and rat hepatocytes in primary cultures. AFB1-induced acute toxicity was visualized by light microscope observation and quantified by measurement of lactic dehydrogenase activity in the medium. Human hepatocytes were susceptible to AFB1-induced cytotoxicity but no evident relationship between the concentration of mycotoxin and the extent of cellular damage was established. (+)-Cyanidanol-3 was not toxic at concentrations up to 2 x 10(-3)M, but no obvious protective effect from AFB1-induced injury was evidenced in human cells. By contrast, rat hepatocytes responded in a dose-related manner to AFB1. (+)-Cyanidanol was toxic at 10(-3)M, but even at this concentration exerted a strong protective effect against AFB1-induced cytotoxicity. Such species differences suggest the existence of metabolic differences in both AFB1 and (+)-cyanidanol-3 activating and deactivating mechanisms. | lld:pubmed |
| pubmed-article:3147113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3147113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3147113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3147113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3147113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3147113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3147113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3147113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3147113 | pubmed:issn | 0248-4900 | lld:pubmed |
| pubmed-article:3147113 | pubmed:author | pubmed-author:GuillouzoAA | lld:pubmed |
| pubmed-article:3147113 | pubmed:author | pubmed-author:CampionJ PJP | lld:pubmed |
| pubmed-article:3147113 | pubmed:author | pubmed-author:BaffetGG | lld:pubmed |
| pubmed-article:3147113 | pubmed:author | pubmed-author:BéguéJ MJM | lld:pubmed |
| pubmed-article:3147113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3147113 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:3147113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3147113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3147113 | pubmed:pagination | 327-33 | lld:pubmed |
| pubmed-article:3147113 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:meshHeading | pubmed-meshheading:3147113-... | lld:pubmed |
| pubmed-article:3147113 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3147113 | pubmed:articleTitle | Differential response of primary cultures of human and rat hepatocytes to aflatoxin B1-induced cytotoxicity and protection by the hepatoprotective agent (+)-cyanidanol-3. | lld:pubmed |
| pubmed-article:3147113 | pubmed:affiliation | Unité de Recherches Hépatologiques U 49, INSERM, Hôpital de Pontchaillou, Rennes, France. | lld:pubmed |
| pubmed-article:3147113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3147113 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3147113 | lld:pubmed |
