Linked Life Data

3146519

Source:http://linkedlifedata.com/resource/pubmed/id/3146519

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-23
pubmed:abstractText
Guinea pigs were fitted with a carotid cannula under anesthesia and used 2 days later for exposure to increasing CO2 concentrations to evaluate their ventilatory response (tidal volume and respiratory frequency) while blood samples were taken for measurement of O2, CO2, and pH. The same measurements were made on another group of animals while changing O2 concentrations. The ventilatory response increased with increasing CO2 concentrations up to 10% while there was little change induced by low oxygen. Decreasing O2 during challenge of animals with 10% CO2 had no effect on the ventilatory response induced by 10% CO2 alone. The ventilatory response of guinea pigs is greater than for other small laboratory animals tested under similar conditions but is not as pronounced as in humans. Challenging guinea pigs with 10% CO2 has revealed that their ventilatory response can be abnormal following pneumotoxicity induced by a variety of agents and blood gas measurements as described here may add to our understanding of such abnormal responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0272-0590
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-76
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Arterial blood gas measurements in guinea pigs and inspired CO2 concentrations for ventilatory performance challenges.
pubmed:affiliation
Department of Industrial Environmental Health Science, University of Pittsburgh, Pennsylvania 15261.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.