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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1988-12-21
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pubmed:abstractText |
An elevation of the intracellular pH and a rise in the cytoplasmic Ca2+ concentration are considered important mitogenic signals which are observed after stimulation by various growth factors. In a preceding report it was demonstrated that the expression of Ha-ras or v-mos in cells transfected with Ha-ras or v-mos, respectively, leads to an activation of the Na+/H+ antiporter and a concomitant rise in intracellular pH (W. Doppler, R. Jaggi, and B. Groner, Gene 54:145-151, 1987). This report describes the effect of the Ha-ras and v-mos oncogenes on intracellular Ca2+ release. The expression of Ha-ras in NIH 3T3 cells carrying a glucocorticoid-inducible transforming Ha-ras gene caused a desensitization of the Ca2+-mobilizing system to serum growth factors. The induction of p21ras in cells carrying the corresponding glucocorticoid-inducible proto-oncogene did not affect the Ca2+ response to growth factors. Conditions leading to the expression of the transforming Ha-ras gene but not those causing the induction of the normal Ha-ras gene yielded an increase in phosphatidylinositol turnover and a concomitant rise in inositol phosphates. Results similar to those obtained with the transforming Ha-ras gene were seen after the expression of v-mos. The data are consistent with a mechanism in which expression of the transforming Ha-ras gene leads to a release of Ca2+ from intracellular stores via elevated levels of inositol trisphosphate.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-228288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-2821623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-2822028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-2883654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-2984954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3001936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3002607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3007485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3013856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3018591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3023051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3037340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3313065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3500722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3918269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-3918272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-6095092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-6148751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-6232463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141785-6610677
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4212-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3141785-Animals,
pubmed-meshheading:3141785-Calcium,
pubmed-meshheading:3141785-Cell Line,
pubmed-meshheading:3141785-Cell Transformation, Neoplastic,
pubmed-meshheading:3141785-Dexamethasone,
pubmed-meshheading:3141785-GTP-Binding Proteins,
pubmed-meshheading:3141785-Gene Expression Regulation,
pubmed-meshheading:3141785-Genes, ras,
pubmed-meshheading:3141785-Growth Substances,
pubmed-meshheading:3141785-Inositol Phosphates,
pubmed-meshheading:3141785-Mice,
pubmed-meshheading:3141785-Oncogenes,
pubmed-meshheading:3141785-Phosphatidylinositols,
pubmed-meshheading:3141785-Sugar Phosphates
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pubmed:year |
1988
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pubmed:articleTitle |
Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos.
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pubmed:affiliation |
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
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pubmed:publicationType |
Journal Article
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