Linked Life Data

3141551

Source:http://linkedlifedata.com/resource/pubmed/id/3141551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-22
pubmed:abstractText
In 14 normal subjects constant TRH infusions for determination of plasma clearance rate (PCR) and half-life of disappearance (t 1/2) of TRH were carried out with simultaneous determination of half-life of disappearance of TRH in serum in vitro (t 1/2p). PCR, t 1/2 and t 1/2p were 1532 +/- 423 ml/min, 6.6 +/- 1.5 min and 16.8 +/- 9.4 min respectively (mean +/- S.D.) and displayed only minor fluctuations when determined repeatedly in the same subjects (coefficients of variation within individuals were 15.1, 10.6 and 7.5% respectively). Simultaneous determination of PCR, t 1/2 and t 1/2p enabled calculation of the half-life of disappearance of TRH in the extravascular tissue compartment (t 1/2t). Values of t 1/2t (6.3 +/- 1.4 min) correlated to t 1/2p (r = 0.95). Activities of TRH-degrading enzymes in tissues and in serum were independent of sex, phase of female menstrual cycle, time of day and of the concentrations of TRH used. The methods employed for this investigation offer the possibility of examining the degradation of TRH and TRH analogues both in the serum and in the extravascular compartment during various conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Intra- and extravascular turnover of thyrotrophin-releasing hormone in normal man.
pubmed:affiliation
Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't