Linked Life Data

3141096

Source:http://linkedlifedata.com/resource/pubmed/id/3141096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-12-12
pubmed:abstractText
Several definitions of response have been used to classify the results of empiric antibiotic therapy in febrile neutropenic patients, but none has become universally accepted. In two consecutive Canadian multicentre randomized trials, outcomes were classified in a scheme which allowed us to assess the effect of different outcome definitions on interpretation of the results of the studies. We found that the use of different outcome definitions resulted not only in variations in absolute response rates, but also affected comparisons among patient groups. Thus, both the adverse prognostic effect of leukemia as an underlying disease and the poorer results obtained using aztreonam-containing regimens were evident only with certain outcome definitions. These results indicate a need to pay careful attention to outcome definitions in interpreting the results of studies of antibiotic therapy in febrile neutropenic patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0147-958X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:3141096-Acute Disease, pubmed-meshheading:3141096-Agranulocytosis, pubmed-meshheading:3141096-Anti-Bacterial Agents, pubmed-meshheading:3141096-Aztreonam, pubmed-meshheading:3141096-Clinical Trials as Topic, pubmed-meshheading:3141096-Cloxacillin, pubmed-meshheading:3141096-Drug Therapy, Combination, pubmed-meshheading:3141096-Fever, pubmed-meshheading:3141096-Humans, pubmed-meshheading:3141096-Infection Control, pubmed-meshheading:3141096-Leukemia, pubmed-meshheading:3141096-Lymphoma, pubmed-meshheading:3141096-Moxalactam, pubmed-meshheading:3141096-Multicenter Studies as Topic, pubmed-meshheading:3141096-Neoplasms, pubmed-meshheading:3141096-Neutropenia, pubmed-meshheading:3141096-Prognosis, pubmed-meshheading:3141096-Random Allocation, pubmed-meshheading:3141096-Tobramycin
pubmed:year
1988
pubmed:articleTitle
The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients.
pubmed:affiliation
National Cancer Institute of Canada, Queen's University, Kingston, Ontario.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study