Linked Life Data

3140921

Source:http://linkedlifedata.com/resource/pubmed/id/3140921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1988-12-8
pubmed:abstractText
The potential mechanism of fluorocarbon emulsion (FCE)-induced anaphylactoid reactions characterized by transient flush and respiratory disturbance in a few patients were elucidated by detecting the immunological response and the blood vessel vasoactive amine content. The passive cutaneous anaphylaxis (PCA) test in rats immunized with FCE was negative. The precipitating FCE reaction antibody (FRA) in sera of rabbits at 20 min and 24 h after i.v. infusion of FCE 10 ml/kg by reversible single radioactive immunodiffusion (RSRI) was positive, the densities of FRA were negatively related to the dilution of FCE (24 h, r = -0.9998). Histamine and 5-hydroxytryptamine (5-HT) content in peripheral blood of rabbits using fluorochromatography were decreased by 79% and 92% respectively at 10 min after i.v. infusion of FCE 10 ml/kg. Platelet counts fell to 67%, WBC to 47% and the ratio of polymorphonuclear cells and lymphocytes (P/L) was depressed by as much as half of that before infusion. Small arterioles of lungs were filled with macrophages. These results indicated that the mechanisms of FCE-induced anaphylactoid reactions did not involve IgE-dependent mediator release (histamine and 5-HT), but was associated with FCE-FRA complex formation and macrophage-stasis in pulmonary vessels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0890-5533
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
505-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Anaphylactoid reactions induced by fluorocarbon blood substitute.
pubmed:affiliation
Department of Toxicology, Institute of Industrial Hygiene and Occupational Diseases, Shanghai, P.R. China.
pubmed:publicationType
Journal Article