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rdf:type |
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lifeskim:mentions |
umls-concept:C0009017,
umls-concept:C0016129,
umls-concept:C0017337,
umls-concept:C0018270,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0678594,
umls-concept:C0679058,
umls-concept:C0871261,
umls-concept:C1283195,
umls-concept:C1414315,
umls-concept:C1547699,
umls-concept:C1561491,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2700640,
umls-concept:C2911692
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pubmed:issue |
19
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pubmed:dateCreated |
1988-11-21
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pubmed:databankReference |
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pubmed:abstractText |
Early growth response gene-1 (Egr-1) is a mouse gene displaying fos-like induction kinetics in diverse cell types following mitogenic stimulation. Egr-1 encodes a protein with "zinc-binding finger" structure. Zinc fingers are a protein structural motif that serve as DNA-binding domains in several transcriptional regulatory proteins. Using low-stringency hybridization with an Egr-1 cDNA probe, we identified a distinct human cDNA (designated EGR2 for early growth response gene-2), which is coregulated with EGR1 by fibroblast and lymphocyte mitogens; however, several stimuli that induce Egr-1 mRNA in PC12 (rat pheochromocytoma) cells do not induce Egr-2 mRNA. The cDNA sequence predicts a protein of 406 amino acids, including three tandem zinc fingers of the Cys2-His2 class. Strikingly, the deduced amino acid sequences of human EGR2 and mouse Egr-1 are 92% identical in the zinc finger region but show no similarity elsewhere. EGR2 maps to human chromosome 10 at bands q21-22. Structure-function analysis of EGR2 and EGR1 proteins should provide insight into the mechanisms linking signal transduction and transcriptional regulation of gene expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-2452975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-2825349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-2831463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-2837652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-2898731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3011240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3025750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3039853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3096579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3124104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3125980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3129290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3130602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3313277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3319186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3330774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3346337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3347253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3422745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3469660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3672127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3785392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-3815523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6092965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6203430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6208611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-656184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6609441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3140236-6872001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7164-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3140236-Amino Acid Sequence,
pubmed-meshheading:3140236-Animals,
pubmed-meshheading:3140236-Base Sequence,
pubmed-meshheading:3140236-Cell Line,
pubmed-meshheading:3140236-Chromosome Mapping,
pubmed-meshheading:3140236-Cloning, Molecular,
pubmed-meshheading:3140236-DNA Probes,
pubmed-meshheading:3140236-DNA-Binding Proteins,
pubmed-meshheading:3140236-Humans,
pubmed-meshheading:3140236-Metalloproteins,
pubmed-meshheading:3140236-Molecular Sequence Data,
pubmed-meshheading:3140236-Rats,
pubmed-meshheading:3140236-Tetradecanoylphorbol Acetate,
pubmed-meshheading:3140236-Zinc
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pubmed:year |
1988
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pubmed:articleTitle |
Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.
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pubmed:affiliation |
Department of Medicine, Howard Hughes Medical Institute, Chicago, IL.
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