Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-11-21
|
| pubmed:abstractText |
A transfontanellar range-gated ultrasound Doppler technique for recording blood flow velocity in an artery on the base of the skull was validated in eight anesthetized newborn lambs during hypo-, normo-, and hypercarbia. Blood flow velocity was linearly related to PaCO2 from 20 to 80 mm Hg; mean blood flow velocity (Vmean) (r = 0.86, p less than 0.001), peak systolic blood flow velocity (r = 0.83, p less than 0.001), and end-diastolic blood flow velocity (r = 0.87, p less than 0.001). Vmean changed 2.0% per mm Hg of PaCO2. A linear relationship was demonstrated between brain blood flow (BBF), as determined by the microsphere method, and PaCO2 (r = 0.91, p less than 0.001), with BBF changing 3.6%/mm Hg of PaCO2. Blood flow velocity was linearly related to BBF in the PaCO2 range studied; Vmean (r = 0.89, p less than 0.001), peak systolic blood flow velocity (r = 0.87, p less than 0.001), and end-diastolic blood flow velocity (r = 0.87, p less than 0.001). However, Vmean predicted only approximately 55% of the change in BBF, which suggests a concomitant change in the cross-sectional area of the artery being studied. Despite this limitation, these data suggest that blood flow velocity, recorded by a transfontanellar range-gated Doppler technique from one of the two main arteries perfusing the brain, provides qualitative information on changes in BBF.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0031-3998
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
423-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3140203-Animals,
pubmed-meshheading:3140203-Animals, Newborn,
pubmed-meshheading:3140203-Blood Flow Velocity,
pubmed-meshheading:3140203-Blood Gas Analysis,
pubmed-meshheading:3140203-Carbon Dioxide,
pubmed-meshheading:3140203-Cerebral Arteries,
pubmed-meshheading:3140203-Cerebrovascular Circulation,
pubmed-meshheading:3140203-Sheep,
pubmed-meshheading:3140203-Ultrasonography
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Intracranial arterial blood flow velocity and brain blood flow during hypocarbia and hypercarbia in newborn lambs: a validation of range-gated Doppler ultrasound flow velocimetry.
|
| pubmed:affiliation |
Department of Pediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|