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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-11-14
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pubmed:abstractText |
The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
238
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-80
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3139458-Adenosine Diphosphate Ribose,
pubmed-meshheading:3139458-Adrenal Medulla,
pubmed-meshheading:3139458-Animals,
pubmed-meshheading:3139458-Antibodies,
pubmed-meshheading:3139458-Botulinum Toxins,
pubmed-meshheading:3139458-Calcium,
pubmed-meshheading:3139458-Catecholamines,
pubmed-meshheading:3139458-Cattle,
pubmed-meshheading:3139458-Cells, Cultured,
pubmed-meshheading:3139458-Chromaffin System,
pubmed-meshheading:3139458-Exocytosis,
pubmed-meshheading:3139458-Poly(ADP-ribose) Polymerases
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pubmed:year |
1988
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pubmed:articleTitle |
Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events.
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pubmed:affiliation |
Division of Biomedical Sciences, King's College, London, England.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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