Linked Life Data

3138865

Source:http://linkedlifedata.com/resource/pubmed/id/3138865

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-10-24
pubmed:abstractText
The secretion of FSH appears to be dominated by factors controlling the inhibition of synthesis and release acting directly at the level of the gonadotrope in the pituitary. Only minimal amounts of GnRH are necessary to stimulate and maintain the secretion of FSH, and, in contrast to LH, the release of FSH is closely linked to the rate of synthesis. Estradiol is a potent inhibitor of FSH release acting directly at the gonadotrope to inhibit mRNA transcription. In vivo, estradiol alone in physiological concentrations cannot maintain plasma concentrations within the normal levels seen during the estrus or menstrual cycle. It is probable that estradiol acts synergistically with inhibin both of which are secreted by the developing follicle. Inhibin secretion in the follicle is dependent on FSH. During the follicular phase in sheep and women peripheral plasma concentrations of inhibin remain unchanged or decline in parallel with those of FSH, and inversely to estradiol. In the luteal phase, the human corpus luteum secretes inhibin under the influence of LH. Thus inhibin together with both estradiol and progesterone secreted by the corpus luteum, accounts for the suppression of FSH and thus follicular development in the luteal phase of the human menstrual cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9750
pubmed:author
pubmed:issnType
Print
pubmed:volume
288
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-40
pubmed:dateRevised
2008-2-12
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The control of FSH secretion.
pubmed:affiliation
MRC Reproductive Biology Unit, Edinburg, Scotland.
pubmed:publicationType
Journal Article, Review