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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-9-29
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pubmed:abstractText |
The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-2892398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-2983330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-3013006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-3259403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-3490178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-3500674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-3864592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-4422075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6372675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6411603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6418058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6587361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6593156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-6957147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-9556656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3137812-9556659
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
304-10
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3137812-Chromosome Mapping,
pubmed-meshheading:3137812-Chromosomes, Human, Pair 6,
pubmed-meshheading:3137812-Complement C4,
pubmed-meshheading:3137812-Complement C4b,
pubmed-meshheading:3137812-Genes, MHC Class I,
pubmed-meshheading:3137812-Genes, MHC Class II,
pubmed-meshheading:3137812-Genetic Linkage,
pubmed-meshheading:3137812-HLA Antigens,
pubmed-meshheading:3137812-HLA-DR Antigens,
pubmed-meshheading:3137812-Haplotypes,
pubmed-meshheading:3137812-Humans,
pubmed-meshheading:3137812-Recombination, Genetic,
pubmed-meshheading:3137812-Steroid 21-Hydroxylase,
pubmed-meshheading:3137812-Steroid Hydroxylases
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pubmed:year |
1988
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pubmed:articleTitle |
Genetic mapping of the 21-hydroxylase locus: estimation of small recombination frequencies.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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