Linked Life Data

3137808

Source:http://linkedlifedata.com/resource/pubmed/id/3137808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1988-10-7
pubmed:abstractText
To study the immunopathogenesis of chronic type B hepatitis, we used a panel of monoclonal antibodies to characterize the intrahepatic mononuclear cell infiltrates in 39 patients with various forms of chronic hepatitis induced by hepatitis B virus (HBV) and, for comparison, in 10 with non-A, non-B (NANB)-induced chronic hepatitis. In portal areas, the OKT4:OKT8 ratio reversed because of the relative increase of OKT8+ cells. The mean intraportal T4:T8 ratio was significantly lower in HBV-associated chronic active hepatitis (CAH) than in chronic persistent hepatitis induced by HBV or NANB viruses. OKT8+ cells were predominant in the infiltrates of periportal areas (piecemeal necrosis) and lobules. As to the activation status of the infiltrates, T10 was found much more frequently on mononuclear infiltrates of piecemeal necrosis and peripheral portion of portal areas in CAH cases, regardless of viral etiology, and its existence was correlated with the severity of CAH. Natural killer cells, killer cells, and B-cells played little role in the pathogenesis of hepatocytolysis. We conclude that T-cell cytotoxicity is the main mechanism of hepatocytolysis, either in lobules or in periportal regions, and that T10 antigen defines a group of cells which may play an important role associated with the formation of piecemeal necrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9270
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
948-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Immunohistochemical studies on intrahepatic lymphocyte infiltrates in chronic type B hepatitis, with special emphasis on the activation status of the lymphocytes.
pubmed:affiliation
Department of Internal Medicine, National Taiwan University, College of Medicine, Taipei, Republic of China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't