Linked Life Data

3136065

Source:http://linkedlifedata.com/resource/pubmed/id/3136065

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-4
pubmed:dateCreated
1988-9-16
pubmed:abstractText
While the concept of a nonsteroidal entity of gonadal origin, which specifically regulates FSH secretion, was proposed over 50 years ago, problems linked to the assay, isolation and characterization of this protein have only recently been solved. The structure of inhibin from follicular fluid origin has been established as a heterodimer consisting of two subunits (alpha and beta) linked by disulfide bridges. The development of antisera specifically directed against the N-terminus part of the alpha-chain of inhibin has allowed the measurement of plasma levels of inhibin, as well as the evaluation of the biological effect of removal of endogenous inhibin. These studies have demonstrated age-related changes in the circulating levels of inhibin in the female rat and support the hypothesis that inhibin represents an important modulator of FSH secretion in this species.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0163
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-18
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Studies of the inhibin family of hormones: a review.
pubmed:affiliation
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, Calif.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't