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pubmed-article:3136025pubmed:abstractTextThe antibody response of inbred and congenic strains of mice immunized with a recombinant Plasmodium vivax circumsporozoite protein was investigated. Only mice of the H-2k and H-2a haplotypes developed antibodies that react with P. vivax sporozoite in an indirect immunofluorescence assay and with the recombinant protein in enzyme-linked immunosorbent assay. Congenic recombinant strains were used to map Ir gene control to the I-Ak locus. A similar pattern of genetic restriction was found when congenic strains were immunized with a carrier-free synthetic peptide corresponding to the repeat region of the P. vivax circumsporozoite protein. The results suggest that the ability of T helper cells to recognize a T cell epitope(s) in the repeat region of the P. vivax circumsporozoite protein is genetically restricted.lld:pubmed
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pubmed-article:3136025pubmed:pagination1119-22lld:pubmed
pubmed-article:3136025pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:3136025pubmed:articleTitleGenetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein.lld:pubmed
pubmed-article:3136025pubmed:affiliationDepartment of Medical and Molecular Parasitology, New York University School of Medicine, New York.lld:pubmed
pubmed-article:3136025pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3136025pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:3136025pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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