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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1988-9-9
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pubmed:abstractText |
The antibody response of inbred and congenic strains of mice immunized with a recombinant Plasmodium vivax circumsporozoite protein was investigated. Only mice of the H-2k and H-2a haplotypes developed antibodies that react with P. vivax sporozoite in an indirect immunofluorescence assay and with the recombinant protein in enzyme-linked immunosorbent assay. Congenic recombinant strains were used to map Ir gene control to the I-Ak locus. A similar pattern of genetic restriction was found when congenic strains were immunized with a carrier-free synthetic peptide corresponding to the repeat region of the P. vivax circumsporozoite protein. The results suggest that the ability of T helper cells to recognize a T cell epitope(s) in the repeat region of the P. vivax circumsporozoite protein is genetically restricted.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
0014-2980
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3136025-Animals,
pubmed-meshheading:3136025-Antibody Formation,
pubmed-meshheading:3136025-Antigens, Protozoan,
pubmed-meshheading:3136025-Antigens, Surface,
pubmed-meshheading:3136025-Genes, MHC Class II,
pubmed-meshheading:3136025-Histocompatibility Antigens Class II,
pubmed-meshheading:3136025-Mice,
pubmed-meshheading:3136025-Oligopeptides,
pubmed-meshheading:3136025-Plasmodium vivax,
pubmed-meshheading:3136025-Protozoan Proteins,
pubmed-meshheading:3136025-Recombinant Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein.
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pubmed:affiliation |
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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