|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1988-9-12
|
|
pubmed:abstractText |
The cell-type specific processing of human pro-enkephalin was determined using a vaccinia recombinant (VV:hPE). The results show that all cell types infected with VV:hPE efficiently synthesize pro-enkephalin following cleavage of the signal peptide after Ala24. In addition, pro-enkephalin is shown to undergo N-linked glycosylation as well as other post-translational modifications. However, only one cell line. AtT-20, was able to efficiently cleave pro-enkephalin to smaller peptides including Met-enkephalin. Some results have been previously reported (Science 232, 1641-1643).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0300-9084
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
70
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
89-97
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3135846-Amino Acid Sequence,
pubmed-meshheading:3135846-Base Sequence,
pubmed-meshheading:3135846-Cell Transformation, Viral,
pubmed-meshheading:3135846-Enkephalins,
pubmed-meshheading:3135846-Hormones,
pubmed-meshheading:3135846-Humans,
pubmed-meshheading:3135846-Molecular Sequence Data,
pubmed-meshheading:3135846-Protein Precursors,
pubmed-meshheading:3135846-Protein Processing, Post-Translational,
pubmed-meshheading:3135846-Recombinant Proteins,
pubmed-meshheading:3135846-Vaccinia virus
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Cell-type specific processing of neuroendocrine precursor proteins using vaccinia recombinants.
|
|
pubmed:affiliation |
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
