Linked Life Data

3133769

Source:http://linkedlifedata.com/resource/pubmed/id/3133769

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-7-29
pubmed:abstractText
The preceding discussion makes it clear that there are multiple determinants, related to the microorganism, the host defense cell, and the presence of activating T cell stimuli that must be considered when examining at the cellular level how and why intracellular pathogens are able to cause infection. From the standpoint of the interaction of the mononuclear phagocyte's antimicrobial mechanisms with T gondii, L donovani, and C psittaci, the determinants which appear to influence directly the outcome of intracellular infection include: a. the magnitude of the phagocyte's respiratory burst capacity; b. the ability to respond specifically and effectively to microbial ingestion with the generation of O2- and H2O2; c. susceptibility to H2O2; and d. the presence of and susceptibility to oxygen-independent mechanisms. T cell dependent enhancement of the mononuclear phagocyte's antimicrobial mechanisms is a particularly critical element in cellular resistance to infection, and thus, host defense. If the activated state is not properly achieved, the macrophage remains susceptible to and perpetuates intracellular infections.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0037-1963
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-11
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Survival of intracellular pathogens within human mononuclear phagocytes.
pubmed:affiliation
Division of Infectious Diseases, Cornell University Medical College, New York, NY 10021.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Review