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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1979-9-27
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pubmed:abstractText |
Effects of antiinflammatory agents and prostaglandins on H+ and HCO-3 secretions and electrical properties were investigated in the amphibian-isolated gastric mucosa. Gastric HCO-3 transport was studied in Rana temporaria fundus, in which H+ secretion had been inhibited with the histamine H2-receptor antagonists metiamide or cimetidine (10(-3) M), and in Necturus antrum, which secreted HCO-3 spontaneously. Hydrocortisone (100-500 microgram/ml) had no effect on H+ or HCO-3 secretion in the fundus. Indomethacin (10(-4) M) was a considerably more potent inhibitor of HCO-3 secretion than of H+ secretion in the fundus and also inhibited HCO-3 transport in the antrum. Fenclofenac (3 x 10(-3) M) almost abolished fundic HCO-3 transport and also depressed H+ secretion. There was a marked fall in transmucosal potential difference and a decrease in electrical resistance in fenclofenac-treated mucosae whereas indomethacin had less effect on electrical properties at the concentrations used here. The prostaglandins, E2, 16,16-dimethyl E2 and I2 all inhibited H+ secretion but only 16,16-dimethyl E2 stimulated HCO-3 secretion. The inhibitory action of indomethacin on HCO-3 secretion was prevented by co-administration of 16,16-dimethyl PGE2 (10(-6) M). It is proposed that the inhibitory action of nonsteroidal antiinflammatory drugs and the stimulatory action of some prostaglandins on HCO-3 secretion contributes to their ulcerogenic and anti-ulcer actions on the gastric mucosa.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Cimetidine,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Metiamide,
http://linkedlifedata.com/resource/pubmed/chemical/Phenyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylacetates,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins, Synthetic
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-5085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
451-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:313351-Animals,
pubmed-meshheading:313351-Anti-Inflammatory Agents,
pubmed-meshheading:313351-Anura,
pubmed-meshheading:313351-Bicarbonates,
pubmed-meshheading:313351-Cimetidine,
pubmed-meshheading:313351-Gastric Juice,
pubmed-meshheading:313351-Gastric Mucosa,
pubmed-meshheading:313351-Hydrocortisone,
pubmed-meshheading:313351-Indomethacin,
pubmed-meshheading:313351-Membrane Potentials,
pubmed-meshheading:313351-Metiamide,
pubmed-meshheading:313351-Phenyl Ethers,
pubmed-meshheading:313351-Phenylacetates,
pubmed-meshheading:313351-Prostaglandins, Synthetic,
pubmed-meshheading:313351-Rana temporaria,
pubmed-meshheading:313351-Secretory Rate
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pubmed:year |
1979
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pubmed:articleTitle |
Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa.
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pubmed:publicationType |
Journal Article,
Comparative Study
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