Linked Life Data

3131509

Source:http://linkedlifedata.com/resource/pubmed/id/3131509

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-7-5
pubmed:abstractText
A hypothetical model of the maturation pathway of Langerhans cells (LC) within an epithelial environment is presented. This model is based on in vitro studies using human gingival organ culture. In this model, T6 (CD1) antigen is induced on a T6(-) intraepithelial population by Interleukin-1 secreted by epithelial cells. This process is abrogated by a locally produced Interleukin-1 inhibitor, ILS. These T6(+) LC then express first HLA-DR and subsequently HLA-DQ surface antigens under the influence of either lipopolysaccharide or gamma interferon. The induction of these Class II antigens on LC is inhibited by prostaglandin E2. It is postulated that these Class II antigen positive LC are then available to function as antigen presenting cells. This hypothesis is consistent with in vitro studies and several in vivo observations. The basis of the hypothesis is the demonstration that locally produced factors may exert an influence on LC behaviour within an epithelial environment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0300-9777
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The regulation of Langerhans cell T6, DR and DQ antigen expression: an hypothesis.
pubmed:affiliation
Department of Social and Preventive Dentistry, University of Queensland Dental School, Brisbane, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't