Linked Life Data

3131482

Source:http://linkedlifedata.com/resource/pubmed/id/3131482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-6-28
pubmed:abstractText
The present study was designed to evaluate the role of gamma-aminobutyric acid (GABA) in the secretory function of cultured chromaffin cells using the method of real-time monitoring. GABA evoked the secretion of catecholamines (CA) from adrenal chromaffin cells in a dose-dependent manner. Bicuculline 10(-5) M inhibited the stimulatory action of GABA. Diazepam 5 X 10(-6) and 2.5 X 10(-5) M facilitated the secretory response evoked by 7 X 10(-5) M GABA by 22% and 96%, respectively, which was antagonized by Ro 15-1788. This finding suggests that GABA-benzodiazepine receptor coupling can function in the secretion of CA from the adrenal chromaffin cells in a manner similar to that observed in the brain. GABA-evoked release of CA was reduced by 1 microM nifedipine to 16% of control, suggesting the involvement of voltage-sensitive Ca2+ channels in the mechanisms of the CA-releasing action of GABA in these cells. From these findings, the involvement of GABAergic mechanisms in the regulation of adrenal medullary function can be proposed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3042
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1765-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Stimulatory action of gamma-aminobutyric acid on catecholamine secretion from bovine adrenal chromaffin cells measured by a real-time monitoring system.
pubmed:affiliation
Life Science Institute, Sophia University, Tokyo, Japan.
pubmed:publicationType
Journal Article