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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-6-20
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pubmed:abstractText |
Lung volume and the pressure-volume (PV) relationships of the lung were determined in excised lungs of an animal model of human systemic lupus erythematosus, which develops in NZB/W mice, and correlated with histopathologic changes. In young, 4-month-old NZB/W mice, and in nonautoimmune BALB/c mice at any age, there were minimal histologic changes or alterations in lung function. The NZB/W mice developed histologic changes with aging. Perivascular, peribronchial, and interstitial changes developed and were associated with a significant reduction in total lung capacity as well as changes in the pressure-volume characteristics of the lung, which are compatible with a restrictive process.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
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pubmed:issn |
0341-2040
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
166
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
107-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3130529-Age Factors,
pubmed-meshheading:3130529-Animals,
pubmed-meshheading:3130529-Elasticity,
pubmed-meshheading:3130529-Lung,
pubmed-meshheading:3130529-Lung Diseases,
pubmed-meshheading:3130529-Lung Volume Measurements,
pubmed-meshheading:3130529-Lupus Erythematosus, Systemic,
pubmed-meshheading:3130529-Mice,
pubmed-meshheading:3130529-Mice, Inbred BALB C,
pubmed-meshheading:3130529-Mice, Inbred NZB,
pubmed-meshheading:3130529-Respiration
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pubmed:year |
1988
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pubmed:articleTitle |
Elastic properties of the excised lungs of NZB/W mice and their correlation with histopathologic changes.
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pubmed:affiliation |
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado, Denver 80206.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
|