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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
1988-6-23
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|
pubmed:abstractText |
Purified human interleukin 6 (IL 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting T cells subliminally activated with phytohemagglutinin (PHA). This response seemed independent of IL 2 but highly dependent on the presence of accessory cells. Indeed, when accessory cell-depleted tonsillar T cells were activated with PHA and exposed to IL 6, only minimal proliferations were observed. A similar result was obtained with IL 1. However, a combination of these two cytokines induced strong proliferations, indicating that IL 1 and IL 6 plays a synergistic role in the interactions between accessory cells and T lymphocytes.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
653-6
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:3130269-Antigen-Presenting Cells,
pubmed-meshheading:3130269-Drug Synergism,
pubmed-meshheading:3130269-Growth Substances,
pubmed-meshheading:3130269-Humans,
pubmed-meshheading:3130269-Interleukin-1,
pubmed-meshheading:3130269-Interleukin-6,
pubmed-meshheading:3130269-Interleukins,
pubmed-meshheading:3130269-Lymphocyte Activation,
pubmed-meshheading:3130269-Receptors, Immunologic,
pubmed-meshheading:3130269-Receptors, Interleukin-2,
pubmed-meshheading:3130269-T-Lymphocytes
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|
pubmed:year |
1988
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|
pubmed:articleTitle |
Synergistic activation of human T cells by interleukin 1 and interleukin 6.
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|
pubmed:affiliation |
Unit of Experimental Medicine, Université Catholique de Louvain, Brussels, Belgium.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
