Linked Life Data

3129686

Source:http://linkedlifedata.com/resource/pubmed/id/3129686

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-6-2
pubmed:abstractText
Both the t(14; 18) and the t(11; 14) chromosomal translocations are associated with human B-cell neoplasms. Sequence analysis of the regions on chromosomes 18q- and 11q- involved in the joining of chromosomes 14 and 18 and of chromosomes 11 and 14 during their respective translocations indicates the involvement of the DH region. There is a deletion of the region between the involved D segment and the JH region, and extranucleotides are present at the joining sites on the 18q- and on the 11q- chromosomes. We have previously reported that the joining region on chromosome 14q+ involved in both the t(11; 14) and the t(14; 18) translocations are structurally identical. We now report that the joining regions on chromosomes 11q- and 18q- involved in these two different translocations are also identical. Thus, these translocations arose by the same mechanisms. The deletions of the region between the involved segment and the JH region must likely occur during either a D-J recombination event on the 18q- and 11q- chromosomes following the translocations or, alternatively, during the D-J recombination event that results in the translocation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-51
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanism.
pubmed:affiliation
Wistar Institute, Philadelphia, Pennsylvania 19104.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.