Linked Life Data

3129440

Source:http://linkedlifedata.com/resource/pubmed/id/3129440

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-5-27
pubmed:abstractText
A fundamental prediction of the hypothesis that critical events in tumour formation are rare is that the tumours develop by clonal expansion. This prediction has been tested by establishing the isozyme content of tumours induced in mosaic animals whose normal tissues contain two distinguishable isozyme activities. The observation that tumours contain activity associated with one or other of the two cell types present in non-neoplastic tissue has been taken to support the contention that the tumours are clonal in origin. Conversely, the presence of both isozyme activities has been taken to mean that the tumours are derived from a large number of cells. There are conflicting reports concerning the clonal origins of chemically induced epidermal tumours. In this report we present evidence that permits a critical resolution of this controversy. The neoplastic epidermal component of the tumours in mosaic animals was separated from the non-neoplastic dermal components. The neoplastic components were derived exclusively from one or other of the cell lineages present within the mosaic, while the dermal non-neoplastic tissue was shown to be derived from both cell lineages. The data support the view that, irrespective of dose or type of carcinogen, the neoplastic portion of a tumour is clonally derived and that analysis of unseparated tumours is confounded by non-neoplastic dermal tissue. The patch size (number of cells in aggregates of like cell type) was established in the target tissue, isolated epidermis.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9533
pubmed:author
pubmed:issnType
Print
pubmed:volume
88 ( Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-12
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Clonal origin of chemically induced papillomas: separate analysis of epidermal and dermal components.
pubmed:affiliation
Northwestern University Medical School, Chicago, IL.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't