Linked Life Data

3129369

Source:http://linkedlifedata.com/resource/pubmed/id/3129369

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-5-27
pubmed:abstractText
In recent years, receptors for calcitriol (the active form of vitamin D3) have been identified in monocytes and activated, but not resting, human B and T lymphocytes suggesting that it may be involved in immune regulation. Because lymphokines are central in the regulation and modulation of immune or inflammatory responses and since the calcium translocation is involved in the mitogen-induced activation of lymphocytes, we thought it interesting to study the role of calcitriol on interferon gamma (IFN-gamma) production in vitro. In this study, we report that calcitriol inhibits the IFN-gamma production by staphylococcal enterotoxin A-stimulated peripheral blood mononuclear cells (PBMC) in a dose-dependent fashion. The inhibitory effect was less potent in calcium ionophore A23187-stimulated PBMC and was absent in resting PBMC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effect of 1,25-dihydroxyvitamin D3 on interferon gamma production in vitro.
pubmed:affiliation
Institute of General Physiology, University of Siena, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't