3128486

Source:http://linkedlifedata.com/resource/pubmed/id/3128486

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0039194, umls-concept:C0041215, umls-concept:C1167395
pubmed:issue	5
pubmed:dateCreated	1988-5-26
pubmed:abstractText	Anti-heart T-cell activity was evaluated by a lymph node cell proliferative assay in isogenic strains of mice immunized with several Trypanosoma cruzi epimastigote and trypomastigote antigenic preparations. In addition, chronically infected animals were boosted with trypomastigote antigens and their lymph node cells were tested by in vitro proliferative responses. Our results indicated that (i) use of allogeneic sources of heart antigens may induce alloreactive responses in T. cruzi-immune T cells, (ii) specific autoimmune T-cell reactivity against self-heart constituents could not be demonstrated after immunization of the host with T. cruzi, and (iii) a proportion of chronically infected mice showed a small but detectable level of auto-anti-heart T-cell reactivity. These results argue against the notion that T. cruzi epitopes cross-reactive with self-heart tissue play a role in initiating T-cell-mediated autoimmunity. Anti-heart autoreactive T cells, generated in a proportion of the animals, may result from heart lesions associated with the infection process.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-15275617, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-216677, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-3099379, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-3507566, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-3510177, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-4201691, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-4209357, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-4587740, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-6174868, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-6196053, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-6404836, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-6790563, http://linkedlifedata.com/resource/pubmed/commentcorrection/3128486-7037950
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0246127
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0019-9567
pubmed:author	pubmed-author:BarcinskiM AMA, pubmed-author:Dos ReisG AGA, pubmed-author:GattassC RCR, pubmed-author:LimaM TMT, pubmed-author:NóbregaA FAF
pubmed:issnType	Print
pubmed:volume	56
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1402-5
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:3128486-Animals, pubmed-meshheading:3128486-Autoimmune Diseases, pubmed-meshheading:3128486-Chagas Disease, pubmed-meshheading:3128486-Lymphocyte Activation, pubmed-meshheading:3128486-Mice, pubmed-meshheading:3128486-Myocardium, pubmed-meshheading:3128486-T-Lymphocytes
pubmed:year	1988
pubmed:articleTitle	Do self-heart-reactive T cells expand in Trypanosoma cruzi-immune hosts?
pubmed:affiliation	Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Brazil.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't