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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1979-9-1
|
| pubmed:abstractText |
Analysis of a murine model of schistosomiasis revealed that both the thymus (T)- and bursa (B)-derived compartments of the immune system are modified during acute infection. The functional capacity of T and B lymphocytes to respond to mitogenic stimuli and the humoral response to thymus-dependent (SRBC) and thymus-independent (DNP-Ficoll) antigens are severely depressed. In addition, it was found that suppressor cells capable of inhibiting the response of normal lymphocytes to SRBC arise during acute infection. Although the splenic frequency of T (theta) and B (Ig+) cells remained constant during chronic infection, quantitative changes were detected in each population. In the T cell pool there was a decrease in the percentage of Ly-1+ cells and a concomitant increase in Ly-1+, 2+, 3+, cells, whereas the B cell pool showed a progressive loss of complement receptor-bearing lymphocytes, which apparently was the result of inactivation of surface complement receptor by a serum factor specifically found in infected mice. Characterization of the serum factor strongly suggests it is an immune complex. Thus, it appears that both suppressor cells and immune complexes contribute to changes noted in the immune system during acute schistosomiasis. Additional studies carried out in mice after unisexual infection revealed that egg production is not a necessary prerequisite for several of the immunologic phenomena associated with acute schistosomiasis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1413-20
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:312841-Animals,
pubmed-meshheading:312841-B-Lymphocytes,
pubmed-meshheading:312841-Binding, Competitive,
pubmed-meshheading:312841-Clone Cells,
pubmed-meshheading:312841-Concanavalin A,
pubmed-meshheading:312841-Female,
pubmed-meshheading:312841-Immunoglobulin M,
pubmed-meshheading:312841-Immunosuppression,
pubmed-meshheading:312841-Lipopolysaccharides,
pubmed-meshheading:312841-Lymphocyte Activation,
pubmed-meshheading:312841-Male,
pubmed-meshheading:312841-Mice,
pubmed-meshheading:312841-Mice, Inbred C57BL,
pubmed-meshheading:312841-Mice, Inbred CBA,
pubmed-meshheading:312841-Schistosoma mansoni,
pubmed-meshheading:312841-Schistosomiasis,
pubmed-meshheading:312841-Spleen,
pubmed-meshheading:312841-T-Lymphocytes
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Characterization of the immunosuppressive state during Schistosoma mansoni infection.
|
| pubmed:publicationType |
Journal Article
|