| pubmed-article:3127825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3127825 | lifeskim:mentions | umls-concept:C0013494 | lld:lifeskim |
| pubmed-article:3127825 | lifeskim:mentions | umls-concept:C0058913 | lld:lifeskim |
| pubmed-article:3127825 | lifeskim:mentions | umls-concept:C0599278 | lld:lifeskim |
| pubmed-article:3127825 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:3127825 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3127825 | pubmed:dateCreated | 1988-5-12 | lld:pubmed |
| pubmed-article:3127825 | pubmed:abstractText | The effects of ecdysone, the steroid molting hormone of arthropods, are of considerable interest both to insect physiologists and to those studying steroid-regulated gene expression. Yet progress in understanding ecdysone receptors has been inhibited by the lack of a suitable highly radioactive hormone analog with high affinity for the receptor. Here we report that the synthetic ecdysteroid 26-iodoponasterone A is one of the most active ecdysones known, inducing half-maximal morphological transformation in Drosophila Kc167 cells when present at 0.5 nM. 26-[125I]Iodoponasterone A can be prepared at a specific activity of 2175 Ci/mmol (1 Ci = 37 GBq) by reaction of the precursor 26-mesylinokosterone with carrier-free Na125I. The radiolabeled material binds to Kc167 cell ecdysone receptors specifically and with affinity (Kd ca. 3.8 X 10(-10) M). Thus, 26-[125I]iodoponasterone A appears to be a superior radioligand for ecdysone receptors on grounds both of affinity and of specific activity. Its ready availability should greatly facilitate studies of these receptors. | lld:pubmed |
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| pubmed-article:3127825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3127825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3127825 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3127825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3127825 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3127825 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3127825 | pubmed:author | pubmed-author:LeeS SSS | lld:pubmed |
| pubmed-article:3127825 | pubmed:author | pubmed-author:NakanishiKK | lld:pubmed |
| pubmed-article:3127825 | pubmed:author | pubmed-author:CherbasPP | lld:pubmed |
| pubmed-article:3127825 | pubmed:author | pubmed-author:CherbasLL | lld:pubmed |
| pubmed-article:3127825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3127825 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:3127825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3127825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3127825 | pubmed:pagination | 2096-100 | lld:pubmed |
| pubmed-article:3127825 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
| pubmed-article:3127825 | pubmed:meshHeading | pubmed-meshheading:3127825-... | lld:pubmed |
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| pubmed-article:3127825 | pubmed:meshHeading | pubmed-meshheading:3127825-... | lld:pubmed |
| pubmed-article:3127825 | pubmed:meshHeading | pubmed-meshheading:3127825-... | lld:pubmed |
| pubmed-article:3127825 | pubmed:meshHeading | pubmed-meshheading:3127825-... | lld:pubmed |
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| pubmed-article:3127825 | pubmed:meshHeading | pubmed-meshheading:3127825-... | lld:pubmed |
| pubmed-article:3127825 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3127825 | pubmed:articleTitle | 26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors. | lld:pubmed |
| pubmed-article:3127825 | pubmed:affiliation | Department of Biology, Indiana University, Bloomington 47405. | lld:pubmed |
| pubmed-article:3127825 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3127825 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3127825 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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