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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-4-28
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pubmed:abstractText |
The capacity of cloned murine Ia-positive BK-BI-2.6.C6 T cells to present protein antigens to antigen-reactive long-term cultured T-cell lines was investigated. Antigen recognition by T-line cells on presenting BK-BI-2.6.C6 T-accessory cells resulted in efficient production of lymphokines. While antigen-dependent T cells with transient interleukin-2 receptor (IL-2R) expression were not induced to proliferate, T cells with constitutive IL-2R expression proliferated in response to the secreted IL-2. Although antigen presentation by BK-BI-2.6.C6 T cells resulted in a slight induction of IL-2R expression on responding T cells, as measured by flow cytometry, this augmentation was much smaller than that induced by antigen-presenting spleen cells. Thus the inability of antigen-presenting T-accessory cells to stimulate proliferation of responding T cells with transient IL-2R expression appears to reflect a lack of signal(s) necessary for the induction of IL-2R up to a level critical for initiation of cell division. This test system represents an ideal model to investigate the nature of signals required, in addition to triggering of the T-cell antigen receptor, for the induction of IL-2R.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-145543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-149171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-2983318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-2983999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-307016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-3086969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-3512709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-3875550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-3919388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-3921611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6090574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6162776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6171431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6173429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6182454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6205080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6222631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6235287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6336592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6403654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6425405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6448898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6448901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6607969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6797272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6804568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6815073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6968771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-6970212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3127326-81860
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3127326-Animals,
pubmed-meshheading:3127326-Antigen-Presenting Cells,
pubmed-meshheading:3127326-Cell Division,
pubmed-meshheading:3127326-Cell Line,
pubmed-meshheading:3127326-Clone Cells,
pubmed-meshheading:3127326-Histocompatibility Antigens Class II,
pubmed-meshheading:3127326-Interleukin-2,
pubmed-meshheading:3127326-Mice,
pubmed-meshheading:3127326-Mice, Inbred Strains,
pubmed-meshheading:3127326-Receptors, Immunologic,
pubmed-meshheading:3127326-Receptors, Interleukin-2,
pubmed-meshheading:3127326-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Evaluation of antigen presentation by a murine Ia+ T-cell clone, BK-BI-2.6.C6.
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pubmed:affiliation |
Institute for Immunology, Johannes Gutenberg Universität, Mainz, West Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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