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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6159
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pubmed:dateCreated |
1988-4-8
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pubmed:abstractText |
In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
332
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3126396-Animals,
pubmed-meshheading:3126396-Antibodies, Monoclonal,
pubmed-meshheading:3126396-Antigens, Surface,
pubmed-meshheading:3126396-H-2 Antigens,
pubmed-meshheading:3126396-Hybridomas,
pubmed-meshheading:3126396-Immune Tolerance,
pubmed-meshheading:3126396-Major Histocompatibility Complex,
pubmed-meshheading:3126396-Mice,
pubmed-meshheading:3126396-Mice, Inbred Strains,
pubmed-meshheading:3126396-Minor Lymphocyte Stimulatory Antigens,
pubmed-meshheading:3126396-Receptors, Antigen, T-Cell,
pubmed-meshheading:3126396-T-Lymphocytes
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pubmed:year |
1988
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pubmed:articleTitle |
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex.
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pubmed:affiliation |
Howard Hughes Medical Institute, Denver, Colorado.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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