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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-4-11
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pubmed:abstractText |
Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic beta-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
229
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3126082-Animals,
pubmed-meshheading:3126082-Calcium,
pubmed-meshheading:3126082-Cell Membrane Permeability,
pubmed-meshheading:3126082-Chondroitin Sulfates,
pubmed-meshheading:3126082-Dose-Response Relationship, Drug,
pubmed-meshheading:3126082-Heparin,
pubmed-meshheading:3126082-Hyperglycemia,
pubmed-meshheading:3126082-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:3126082-Inositol Phosphates,
pubmed-meshheading:3126082-Islets of Langerhans,
pubmed-meshheading:3126082-Mice,
pubmed-meshheading:3126082-Mice, Obese,
pubmed-meshheading:3126082-Obesity,
pubmed-meshheading:3126082-Sugar Phosphates
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pubmed:year |
1988
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pubmed:articleTitle |
Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic beta-cells.
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pubmed:affiliation |
Department of Medical Cell Biology, University of Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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