rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
1988-3-30
|
pubmed:abstractText |
Four anti-T lymphocyte monoclonal antibodies were produced by the hybridoma technique. Percentages of miscellaneous labelled cell suspensions, as profiles of fluorescent histograms, showed a reactivity of these 4 reagents quite comparable to that observed with anti-CD3 monoclonal antibodies. Labelling summation studies, cell-sorting studies and blocking experiments gave similar results as gave other anti-CD3 reagents. Biochemical study and functional tests: modulation effects and mitogenic properties, argued for the belonging of these 4 antibodies to the CD3 cluster. The actual data concerning the CD3 molecule are briefly resumed to underline the interest of such antibodies in the understanding of T-lymphocyte activation mechanisms during the immune response.
|
pubmed:language |
fre
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0369-8114
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1285-91
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3125512-Animals,
pubmed-meshheading:3125512-Antibodies, Monoclonal,
pubmed-meshheading:3125512-Antibody Specificity,
pubmed-meshheading:3125512-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3125512-Antigens, Surface,
pubmed-meshheading:3125512-Flow Cytometry,
pubmed-meshheading:3125512-Fluorescein-5-isothiocyanate,
pubmed-meshheading:3125512-Fluoresceins,
pubmed-meshheading:3125512-Fluorescent Dyes,
pubmed-meshheading:3125512-Hybridomas,
pubmed-meshheading:3125512-Leukemia, Lymphoid,
pubmed-meshheading:3125512-Lymphocyte Activation,
pubmed-meshheading:3125512-Mice,
pubmed-meshheading:3125512-Mice, Inbred BALB C,
pubmed-meshheading:3125512-Mitosis,
pubmed-meshheading:3125512-T-Lymphocytes,
pubmed-meshheading:3125512-Thiocyanates
|
pubmed:year |
1987
|
pubmed:articleTitle |
[Anti-CD3 monoclonal antibodies. Characterization and function].
|
pubmed:affiliation |
Centre Régionale de Transfusion Sanguine, Rennes, France.
|
pubmed:publicationType |
Journal Article,
English Abstract
|