Linked Life Data

3123118

Source:http://linkedlifedata.com/resource/pubmed/id/3123118

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-3-4
pubmed:abstractText
1. The renal responses to the dipeptides gamma-L-glutamyl-L-dopa (gludopa) and gamma-L-glutamyl-L-tyrosine (glutyrosine) were compared when given intravenously in six normal male volunteers. 2. Gludopa is natriuretic and diuretic at a dose of 25 micrograms min-1 kg-1. At the same dose, glutyrosine had no effect on the volume or sodium content of the urine. 3. There was a 400-600-fold increase in urine dopamine output after gludopa; there was no conversion of glutyrosine to dopamine. 4. Gludopa significantly inhibited plasma renin activity, whereas with glutyrosine there was a non-significant increase. 5. Gludopa is a potent pro-drug for renal dopamine production and exerts natriuretic and hormonal effects. Glutyrosine appears to be inactive. The results support the contention that circulating L-dopa is the important physiological precursor for renal dopamine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-40
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
A comparison of the renal actions of gamma-L-glutamyl-L-dopa and gamma-L-glutamyl-L-tyrosine in normal man.
pubmed:affiliation
Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, U.K.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't