| pubmed-article:3123105 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0003242 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3123105 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3123105 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3123105 | pubmed:dateCreated | 1988-3-23 | lld:pubmed |
| pubmed-article:3123105 | pubmed:abstractText | Rabbit antisera raised against eight monoclonal antibodies (MoAb) binding to distinct mycobacterial antigens revealed individual anti-idiotype specificities following cross-absorption with normal mouse globulin. Only one of these antibodies (Rb71), directed towards an M. tuberculosis-specific epitope on the 38 kD protein antigen was able to stimulate mouse T cell responses which had 'internal image' characteristics. This was demonstrated by anti-Id induced in vitro proliferation of Lyt 1.2+ T cells and the elicitation of delayed type hypersensitivity (DTH) foot pad reactions in antigen stimulated BALB/c mice. The DTH reaction was equally strong in mice sensitized with either M. tuberculosis or M. bovis soluble extracts, thus showing a greater degree of cross-reactivity than antibody binding of the corresponding TB71 MoAb. The immunizing potency of the anti-Id in vivo was demonstrable in three strains of mice following injection of Rb71 emulsified with incomplete Freund's adjuvant. These mice showed 38 kD antigen induced DTH-reactions as well as in vitro proliferation of spleen cells. The display of T cell stimulatory internal image by anti-Id may be interpreted as a consequence of binding specificity of TB71 MoAb of a T cell epitope present in the 38 kD antigen. | lld:pubmed |
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| pubmed-article:3123105 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3123105 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3123105 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3123105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3123105 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3123105 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3123105 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:3123105 | pubmed:author | pubmed-author:IvanyiJJ | lld:pubmed |
| pubmed-article:3123105 | pubmed:author | pubmed-author:Praputpittaya... | lld:pubmed |
| pubmed-article:3123105 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3123105 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:3123105 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3123105 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3123105 | pubmed:pagination | 307-15 | lld:pubmed |
| pubmed-article:3123105 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3123105 | pubmed:meshHeading | pubmed-meshheading:3123105-... | lld:pubmed |
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| pubmed-article:3123105 | pubmed:meshHeading | pubmed-meshheading:3123105-... | lld:pubmed |
| pubmed-article:3123105 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3123105 | pubmed:articleTitle | Stimulation by anti-idiotype antibody of murine T cell responses to the 38 kD antigen of Mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:3123105 | pubmed:affiliation | MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. | lld:pubmed |
| pubmed-article:3123105 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3123105 | lld:pubmed |
