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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-3-23
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pubmed:abstractText |
Rabbit antisera raised against eight monoclonal antibodies (MoAb) binding to distinct mycobacterial antigens revealed individual anti-idiotype specificities following cross-absorption with normal mouse globulin. Only one of these antibodies (Rb71), directed towards an M. tuberculosis-specific epitope on the 38 kD protein antigen was able to stimulate mouse T cell responses which had 'internal image' characteristics. This was demonstrated by anti-Id induced in vitro proliferation of Lyt 1.2+ T cells and the elicitation of delayed type hypersensitivity (DTH) foot pad reactions in antigen stimulated BALB/c mice. The DTH reaction was equally strong in mice sensitized with either M. tuberculosis or M. bovis soluble extracts, thus showing a greater degree of cross-reactivity than antibody binding of the corresponding TB71 MoAb. The immunizing potency of the anti-Id in vivo was demonstrable in three strains of mice following injection of Rb71 emulsified with incomplete Freund's adjuvant. These mice showed 38 kD antigen induced DTH-reactions as well as in vitro proliferation of spleen cells. The display of T cell stimulatory internal image by anti-Id may be interpreted as a consequence of binding specificity of TB71 MoAb of a T cell epitope present in the 38 kD antigen.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-1084484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-2428751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-2431994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-2579419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-2581251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-3106197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-3322615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-3923611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-3952505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-4235134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-4598017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-50400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6085753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6166820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6332875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6505692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-66784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6788881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-69518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3123105-6977615
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3123105-Animals,
pubmed-meshheading:3123105-Antibodies, Anti-Idiotypic,
pubmed-meshheading:3123105-Antigens, Bacterial,
pubmed-meshheading:3123105-Cell Division,
pubmed-meshheading:3123105-Hypersensitivity, Delayed,
pubmed-meshheading:3123105-Immunoglobulin Idiotypes,
pubmed-meshheading:3123105-Lymphocyte Activation,
pubmed-meshheading:3123105-Mice,
pubmed-meshheading:3123105-Mice, Inbred Strains,
pubmed-meshheading:3123105-Mycobacterium tuberculosis,
pubmed-meshheading:3123105-Rabbits,
pubmed-meshheading:3123105-Spleen,
pubmed-meshheading:3123105-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Stimulation by anti-idiotype antibody of murine T cell responses to the 38 kD antigen of Mycobacterium tuberculosis.
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pubmed:affiliation |
MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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pubmed:publicationType |
Journal Article
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