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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-1-27
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pubmed:abstractText |
Besides botulinum C2 toxin, Clostridium botulinum type C produces another ADP-ribosyltransferase, which we termed 'C3'. ADP-ribosyltransferase C3 has a molecular mass of 25 kDa and modifies 21-24 kDa protein(s) in platelet and brain membranes. C3 was about 1000 times more potent than botulinum C1 toxin in ADP-ribosylation of membrane proteins. C3-catalysed ADP-ribosylation of the 21-24 kDa protein(s) was decreased by stable guanosine triphosphates, with the potency order GTP[S] much greater than p[NH]ppG greater than p[CH2]ppG. GTP[S] inhibited the ADP-ribosylation caused by C3 by maximally 70-80%, with half-maximal and maximal effects occurring at 0.3 and 10 microM-GTP[S] respectively. The concomitant addition of GTP decreased the inhibitory effect of GTP[S]. GTP[S]-induced inhibition of ADP-ribosylation was resistant to washing of pretreated platelet membranes. The data suggest that the novel botulinum ADP-ribosyltransferase C3 modifies eukaryotic 21-24 kDa guanine nucleotide-binding protein(s).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-188466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-208069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-2859967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3005866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3084494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3086320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3096731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3100333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3103658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3569302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3736664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3805032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-3827891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6116620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6175245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6236295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6327672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6437813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6643573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3122724-6785232
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Clostridium botulinum toxoid,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine 5'-O-(3-Thiotriphosphate),
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylyl Imidodiphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pentosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Toxoids,
http://linkedlifedata.com/resource/pubmed/chemical/guanosine...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3122724-ADP Ribose Transferases,
pubmed-meshheading:3122724-Adenosine Diphosphate Ribose,
pubmed-meshheading:3122724-Blood Platelets,
pubmed-meshheading:3122724-Blood Proteins,
pubmed-meshheading:3122724-Cell Membrane,
pubmed-meshheading:3122724-Clostridium botulinum,
pubmed-meshheading:3122724-Guanine Nucleotides,
pubmed-meshheading:3122724-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:3122724-Guanosine Triphosphate,
pubmed-meshheading:3122724-Guanylyl Imidodiphosphate,
pubmed-meshheading:3122724-Humans,
pubmed-meshheading:3122724-Membrane Proteins,
pubmed-meshheading:3122724-Pentosyltransferases,
pubmed-meshheading:3122724-Thionucleotides,
pubmed-meshheading:3122724-Toxoids
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pubmed:year |
1987
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pubmed:articleTitle |
ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide.
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pubmed:affiliation |
Rudolf-Buchheim-Institut für Pharmakologie der Universität Giessen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
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