Linked Life Data

3122292

Source:http://linkedlifedata.com/resource/pubmed/id/3122292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-2-11
pubmed:abstractText
Carbamylcholine, but not GTP gamma S, stimulated the production of [3H]inositol mono-, bis- and trisphosphate in intact tumoral insulin-producing cells (RINm5F line) prelabelled with myo-[2-3H(N)]inositol. On the contrary, GTP gamma S, but not carbamylcholine, stimulated the production of [3H]inositol mono-, bis- and trisphosphates in a subcellular particulate fraction derived from the prelabelled RINm5F cells. When the latter cells were first treated by digitonine, carbamylcholine or GTP caused a modest stimulation of [3H]inositol 1-phosphate production. However, in the presence of both GTP and carbamylcholine, the production of [3H]inositol 1-phosphate was much higher: it exceeded the value computed by summing the individual responses to each of these two agents, and reached the same level as that recorded in the presence of GTP gamma S. It is speculated that a GTP-binding regulatory protein, probably distinct from either Ns or Ni, couples the occupancy of muscarinic receptor to the activation of phospholipase C in pancreatic islet cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-55
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Possible role of a GTP-binding protein in the activation of phospholipase C by carbamylcholine in tumoral insulin-producing cells.
pubmed:affiliation
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't