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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1988-2-23
|
| pubmed:abstractText |
The antiproliferative activity of recombinant human interferon (rIFN)-beta and rIFN-gamma, alone or in combination, against a human colon cancer cell line (RPMI 4788) was examined in vitro and in nude mice. rIFN-beta and rIFN-gamma interacted synergistically in vitro. In experimental pulmonary metastasis and intraabdominal carcinomatosis in nude mice, rIFN-beta and rIFN-gamma were administered iv and ip, respectively, alone or in combination, for 10 consecutive days beginning 2 days after RPMI 4788 cells were inoculated. In both models, rIFN-beta and rIFN-gamma alone had significant antitumor effects compared with the saline-control group. Combined administration of rIFN-beta and rIFN-gamma resulted in marked antitumor effects. In the pulmonary metastasis model, there were no pulmonary metastatic nodules in the group treated with the combination of rIFN-beta and rIFN-gamma (P less than 0.001), while there were 324.6 +/- 83.1 (mean +/- SD) nodules in the control group. In the intraabdominal carcinomatosis model, the mean survival time was 114.0 +/- 8.2 days (P less than 0.01) for the combination therapy group, but only 41.8 +/- 5.6 days for the control group. These results suggest that combined treatment with rIFN-beta and rIFN-gamma might be a promising therapy for pulmonary metastasis and intraabdominal carcinomatosis of human cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0910-5050
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1258-65
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3121561-Abdominal Neoplasms,
pubmed-meshheading:3121561-Animals,
pubmed-meshheading:3121561-Cell Division,
pubmed-meshheading:3121561-Colonic Neoplasms,
pubmed-meshheading:3121561-Drug Combinations,
pubmed-meshheading:3121561-Drug Synergism,
pubmed-meshheading:3121561-Interferon Type I,
pubmed-meshheading:3121561-Interferon-gamma,
pubmed-meshheading:3121561-Lung Neoplasms,
pubmed-meshheading:3121561-Male,
pubmed-meshheading:3121561-Mice,
pubmed-meshheading:3121561-Mice, Inbred BALB C,
pubmed-meshheading:3121561-Mice, Nude,
pubmed-meshheading:3121561-Neoplasm Transplantation,
pubmed-meshheading:3121561-Neoplasms, Experimental,
pubmed-meshheading:3121561-Recombinant Proteins,
pubmed-meshheading:3121561-Transplantation, Heterologous,
pubmed-meshheading:3121561-Tumor Cells, Cultured
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Antitumor effect of recombinant human interferon-beta and interferon-gamma in combination against human colon cancer cell line in vitro and in nude mice.
|
| pubmed:affiliation |
First Department of Surgery, Okayama University Medical School.
|
| pubmed:publicationType |
Journal Article
|